Droplet-based microfluidics offers a fast, simple, high-throughput method to run reactions at very small volumes. The AssayMark™ platform can be used with our new PDrop™ chips for complete control over reaction conditions:
- Droplet volume (1-40 nL)
- Droplet generation frequency
- Droplet spacing in m™icrofluidic channel
- Pause droplets in channel (for longer running assays that require longer mixing or incubation time or for imaging)*
- Create sample gradients over droplets – full control over granularity of sample concentration over number of droplets*
- Mix droplets
- Incubate/ thermal-cycling
*Unique to the AssayMark Platform over existing droplet microfluidic systems
Example assays that could be performed using PDrop™:
- High-throughput combinatorial screening (I): Low sample/reagent volume (1-10 nL), PK/PD studies, pharmacogenomics
- High-throughput combinatorial screening (II): Test pair of drugs at varying concentration gradients for (synergistic) drug-drug interactions